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Comprehensive Guide
Cardiovascular disease remains the #1 cause of death worldwide. This guide covers the evidence-based supplements, advanced biomarkers, lipid panel optimization, blood pressure protocols, and endothelial function strategies that go far beyond “eat less saturated fat and exercise more.”
12
Evidence-based supplements
8
Advanced biomarkers
7
Key landmark studies
3
Progressive protocol levels
The Stakes
Heart disease kills more people than every cancer combined. The good news: 80% of cardiovascular disease is preventable.
Critical Interaction
If you take a statin, this may be the single most important section of this entire guide.
Statins (atorvastatin, rosuvastatin, simvastatin, pravastatin) work by inhibiting HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis. This is the same enzyme pathway that produces Coenzyme Q10 (CoQ10). As a result, every statin on the market depletes circulating CoQ10 levels by 25-54%, depending on the drug and dose.
CoQ10 is the electron carrier in the mitochondrial electron transport chain — without it, your cells cannot efficiently produce ATP (energy). The heart has the highest mitochondrial density of any organ and therefore the highest CoQ10 demand. Depleting CoQ10 in the organ you are trying to protect is a significant unintended consequence that is rarely discussed with patients.
Symptoms of Statin-Induced CoQ10 Depletion
Bottom line: If you are on a statin, supplementing 200-300 mg of ubiquinol (reduced CoQ10) daily is not optional — it is essential. Multiple clinical trials show CoQ10 supplementation reduces statin-associated myalgia by 40-75%. Some forward-thinking cardiologists now co-prescribe CoQ10 with every statin prescription.
Evidence-Based Supplements
Ranked by evidence quality. Each entry includes mechanism of action, dosing, form recommendations, and safety notes.
100-300 mg ubiquinol daily
Coenzyme Q10 is essential for mitochondrial ATP production in every cell, but cardiac muscle has the highest CoQ10 concentration of any tissue because the heart never rests. CoQ10 is a powerful lipid-soluble antioxidant that protects LDL particles from oxidation — and it is oxidized LDL that initiates atherosclerotic plaque formation. CoQ10 also improves endothelial function, reduces blood pressure (meta-analysis: -11 mmHg systolic), and is depleted by statins by 25-54%. Clinical trials in heart failure patients (Q-SYMBIO trial) showed CoQ10 reduced cardiovascular mortality by 43% over 2 years.
Use ubiquinol (reduced form), not ubiquinone — ubiquinol has 3-8x better absorption, especially after age 40 when conversion efficiency declines. Take with a fat-containing meal. Kaneka QH is the most studied branded form. Start at 100 mg; increase to 200-300 mg if on a statin or over 60.
2-4 g combined EPA+DHA daily (emphasize EPA)
EPA and DHA are incorporated into cell membranes throughout the cardiovascular system, improving membrane fluidity and receptor function. EPA directly competes with arachidonic acid for COX and LOX enzymes, shifting eicosanoid production from pro-inflammatory (thromboxane A2, PGE2) to anti-inflammatory and anti-thrombotic (PGI3, TXA3). The REDUCE-IT trial demonstrated that 4 g/day of pure EPA reduced major cardiovascular events by 25% and cardiovascular death by 20%. Omega-3s lower triglycerides by 15-30%, reduce blood pressure, decrease arterial stiffness, and stabilize atherosclerotic plaques.
Triglyceride form absorbs 70% better than ethyl ester. Take with the fattiest meal of the day. Look for IFOS 5-star certification for purity. EPA is the primary cardiovascular driver — choose products with high EPA:DHA ratio. Target an omega-3 index above 8% (finger-prick test available).
300-400 mg elemental magnesium daily
Magnesium is required for over 600 enzymatic reactions, including those regulating cardiac electrical conduction, vascular smooth muscle tone, and blood pressure. Magnesium deficiency — affecting over 50% of adults — directly increases risk of hypertension, arrhythmias, coronary artery spasm, and sudden cardiac death. Magnesium blocks L-type calcium channels in vascular smooth muscle, promoting vasodilation and reducing peripheral resistance. It also inhibits aldosterone secretion and improves insulin sensitivity, both of which lower blood pressure. Meta-analyses show magnesium supplementation reduces systolic BP by 3-5 mmHg and diastolic by 2-3 mmHg.
Magnesium taurate is ideal for cardiac support — taurine synergistically supports heart rhythm and blood pressure. Glycinate is excellent for absorption and sleep. Avoid oxide (4% bioavailability). Split dose: half in the morning, half before bed. Pair with potassium for maximal blood pressure benefit.
2,000-4,000 FU (fibrinolytic units) daily
Nattokinase is a serine protease enzyme derived from natto (fermented soybeans), a traditional Japanese food. It has direct fibrinolytic activity — it breaks down fibrin, the structural protein in blood clots. Unlike pharmaceutical thrombolytics that work acutely, nattokinase provides ongoing low-level fibrinolytic support when taken daily. Randomized controlled trials show nattokinase reduces fibrinogen levels, lowers blood viscosity, and modestly decreases blood pressure (systolic -3 to -6 mmHg). It may also reduce factor VIII and von Willebrand factor, further supporting healthy blood flow. The mechanism is dose-dependent and clinically relevant at 2,000+ FU daily.
Take on an empty stomach (morning or before bed) for best absorption. Ensure the product is vitamin K2-free (some natto-derived supplements contain K2, which could affect warfarin users). Contraindicated with anticoagulant medications — consult your cardiologist. NSK-SD is a well-studied, vitamin K2-removed form. Effects build over 2-4 weeks.
600-1,200 mg aged garlic extract daily
Aged garlic extract contains S-allylcysteine (SAC) and other organosulfur compounds that inhibit cholesterol synthesis, reduce LDL oxidation, decrease platelet aggregation, and improve endothelial function. The AGE at Heart trial demonstrated that AGE reduced coronary artery calcium progression by 80% compared to placebo over 12 months — one of the most striking results in cardiovascular supplement research. AGE also reduces blood pressure (meta-analysis: -8.3 mmHg systolic in hypertensive subjects), lowers homocysteine, and has anti-inflammatory effects through NF-kB inhibition.
Aged garlic extract is vastly superior to raw garlic or garlic oil supplements — the aging process (12-20 months) converts harsh, unstable allicin into stable, bioavailable SAC. Kyolic is the most studied brand with 30+ clinical trials. Take in divided doses with meals. Well-tolerated, no garlic breath.
100-200 mcg MK-7 daily
Vitamin K2 activates matrix Gla protein (MGP), which is the body's most potent inhibitor of arterial calcification. Without adequate K2, calcium deposits in arterial walls instead of bones — driving atherosclerosis and osteoporosis simultaneously. The Rotterdam Study (4,807 subjects, 7-10 year follow-up) found that high vitamin K2 intake reduced cardiovascular mortality by 57% and reduced aortic calcification. K2 works synergistically with vitamin D3: D3 increases calcium absorption, and K2 directs that calcium to bones and teeth, away from soft tissues and arteries.
MK-7 (from natto) has the longest half-life (72 hours) of any K2 form, providing steady-state arterial protection. MK-4 has a short half-life (1-2 hours) and requires much higher doses. Always pair with vitamin D3. CRITICAL: vitamin K2 is contraindicated with warfarin (Coumadin), which works by blocking vitamin K. If on warfarin, consult your doctor before supplementing.
1-3 g daily
Taurine is the most abundant free amino acid in cardiac muscle. It stabilizes cell membranes, regulates calcium homeostasis in cardiomyocytes, and acts as an antioxidant. Taurine deficiency in animal models causes dilated cardiomyopathy that reverses with supplementation. In human trials, taurine supplementation reduces blood pressure (meta-analysis: -3.4 mmHg systolic), improves endothelial function, decreases arterial stiffness, and lowers homocysteine. A 2023 Science paper found that taurine levels decline with age and that taurine supplementation extended healthspan in multiple animal models, with cardiovascular benefits being a primary driver.
One of the safest supplements — taurine has been consumed in energy drinks for decades with no adverse effects at typical doses. Most effective when combined with magnesium (magnesium taurate provides both). Take between meals. Japan's long-lived populations consume high taurine through seafood-rich diets.
500-1,000 mg bergamot polyphenol extract daily
Bergamot citrus from Calabria, Italy contains unique polyphenol flavonoids (brutieridin and melitidin) that inhibit HMG-CoA reductase — the same enzyme targeted by statins — plus activate AMPK, the cellular energy sensor. Clinical trials show bergamot extract reduces total cholesterol by 20-30%, LDL-C by 24-36%, triglycerides by 30-40%, and increases HDL-C by 22-40%. These effects are comparable to low-to-moderate dose statins. Bergamot also reduces blood glucose, improves insulin sensitivity, and decreases oxidized LDL — the form that actually initiates plaque.
Look for standardized polyphenol extracts (Bergamonte or Bergavit are well-studied forms). Take before meals. Can be combined with red yeast rice for a natural statin-like approach. Effects are dose-dependent and take 4-8 weeks to manifest on lipid panels. Not the same as bergamot essential oil — only oral polyphenol extracts have cardiovascular data.
1,200-2,400 mg daily (standardized to 10 mg monacolin K)
Red yeast rice naturally contains monacolin K, which is chemically identical to lovastatin (Mevacor) — a prescription statin. It inhibits HMG-CoA reductase, reducing hepatic cholesterol synthesis and upregulating LDL receptor expression. The CCSPS trial (China Coronary Secondary Prevention Study, 4,870 patients) found red yeast rice reduced recurrent heart attacks by 45%, coronary death by 33%, and total mortality by 33% over 4.5 years. These are among the most impressive cardiovascular outcomes ever demonstrated by a supplement.
Because it contains a statin, red yeast rice carries the same considerations: CoQ10 depletion (always co-supplement), potential muscle effects, and liver enzyme monitoring. Quality varies enormously — some products contain citrinin (a nephrotoxic mycotoxin). Only use third-party tested, citrinin-free products. Not recommended in combination with prescription statins. Regulatory status varies by country.
6-8 mmol nitrate daily (400-500 mL juice or concentrated shot)
Dietary nitrate from beetroot is converted by oral bacteria to nitrite, then to nitric oxide (NO) in the blood. NO is the primary endogenous vasodilator — it relaxes arterial smooth muscle, reduces peripheral resistance, and lowers blood pressure. NO also inhibits platelet aggregation, reduces LDL oxidation, decreases endothelial inflammation, and prevents smooth muscle cell proliferation in arterial walls. Meta-analyses of 16+ RCTs show beetroot juice reduces systolic BP by 4-10 mmHg and diastolic by 2-5 mmHg. Effects are strongest in hypertensive individuals.
Beetroot juice, concentrated beetroot shots, or beetroot powder all work — the key is nitrate dose (6-8 mmol). CRITICAL: do not use antibacterial mouthwash (chlorhexidine, cetylpyridinium) — it kills the oral bacteria required for nitrate conversion, completely eliminating the blood pressure benefit. Also avoid antacids (reduce stomach nitrite conversion). Peak effect occurs 2-3 hours after ingestion. Can be combined with L-citrulline (3-6 g) for enhanced NO production through a complementary pathway.
450-900 mg standardized extract (1.8% vitexin) daily
Hawthorn has centuries of use in traditional European medicine for cardiac support. Modern research validates its mechanisms: hawthorn oligomeric procyanidins (OPCs) inhibit angiotensin-converting enzyme (ACE), increase coronary blood flow, improve myocardial contractility (positive inotrope), and have antioxidant activity. The SPICE trial (2,681 NYHA class II-III heart failure patients) showed hawthorn reduced cardiac mortality at 6 months. Other trials demonstrate modest blood pressure reduction and improved exercise tolerance in heart failure.
Use standardized extracts (WS 1442 is the most studied at 450 mg twice daily). Effects build gradually over 6-12 weeks. Hawthorn may potentiate cardiac glycosides (digoxin) — use with caution if on this medication. Generally well-tolerated with minimal side effects. Best used as part of a comprehensive cardiovascular support stack rather than as a standalone intervention.
500-1,000 mg bark extract daily
Arjuna is an Ayurvedic cardiotonic with over 3,000 years of traditional use. Modern research identifies its active compounds — arjunolic acid, arjunic acid, and arjungenin — as having cardioprotective properties. Clinical trials show Arjuna reduces blood pressure, decreases total and LDL cholesterol, improves endothelial function, and has antioxidant activity comparable to vitamin E. A randomized trial in stable angina patients found Arjuna reduced anginal frequency by 50% and improved exercise tolerance. It also demonstrates mild positive inotropic effects, strengthening cardiac contractility without increasing oxygen demand.
Use standardized bark extract. Can be taken as a powder mixed with warm water (traditional method) or in capsule form. Most trials use 500 mg twice daily with meals. Well-tolerated, but may interact with anticoagulants and antihypertensives — monitor blood pressure. Limited Western clinical trial data compared to other supplements on this list, but a growing evidence base supports its traditional use.
Disclaimer: Supplements are not a replacement for medical treatment. Always consult your cardiologist or healthcare provider before starting a new supplement regimen, especially if you take medications (statins, blood thinners, antihypertensives) or have existing cardiovascular conditions. The information here is educational, not prescriptive. See our full disclaimer.
Want This Personalized?
This guide gives you the science. A CryoCove coach gives you the personalization — the right dose, timing, and integration with your other 8 pillars.
Beyond Standard Labs
Standard lipid panels are a starting point, not the finish line. These markers paint the complete picture of cardiovascular risk.
Apolipoprotein B
Standard: < 130 mg/dL
Optimal: < 80 mg/dL (general), < 60 mg/dL (high risk)
The single best predictor of cardiovascular risk. One apoB molecule per atherogenic particle (LDL, VLDL, IDL, Lp(a)). Tells you the actual number of artery-damaging particles, not just cholesterol mass.
Lipoprotein(a)
Standard: < 50 nmol/L or < 30 mg/dL
Optimal: < 30 nmol/L or < 14 mg/dL
Genetically determined atherogenic particle. Elevated Lp(a) independently triples cardiovascular risk. 80-90% genetic — test once in your lifetime to know your baseline. Cannot be meaningfully lowered with current supplements or statins.
LDL Particle Number
Standard: < 1,300 nmol/L
Optimal: < 1,000 nmol/L
Measures the total count of LDL particles (not cholesterol mass). More accurate than LDL-C because small, dense LDL particles carry less cholesterol each but are more atherogenic. Discordance between LDL-C and LDL-P is common and clinically significant.
High-Sensitivity C-Reactive Protein
Standard: < 3.0 mg/L
Optimal: < 0.5 mg/L
Measures systemic inflammation, which drives atherosclerotic plaque instability and rupture. Elevated hs-CRP doubles cardiovascular risk independent of cholesterol levels. The JUPITER trial showed that treating elevated hs-CRP (even with normal LDL-C) reduced cardiovascular events by 44%.
Coronary Artery Calcium Score
Standard: 0 (zero = no detectable plaque)
Optimal: 0 at any age. Score > 100 indicates significant plaque.
Non-contrast CT scan that directly images calcium deposits (a marker of atherosclerotic plaque) in coronary arteries. A score of zero is profoundly reassuring. The most powerful single risk-stratification test — directly measures disease rather than estimating risk from surrogate markers.
EPA + DHA as % of Red Blood Cell Membranes
Standard: > 4% (deficient < 4%)
Optimal: > 8%
Reflects 3-4 months of omega-3 intake. An index below 4% is associated with the highest risk of sudden cardiac death. Above 8% is associated with the lowest risk — a 90% reduction in SCD compared to the lowest quintile.
Homocysteine
Standard: < 15 μmol/L
Optimal: < 7 μmol/L
Amino acid that damages endothelial cells when elevated, promoting atherosclerosis, clot formation, and arterial stiffness. Indicates methylation status and B-vitamin sufficiency (B12, B6, folate). Easily modifiable with targeted supplementation.
Fasting Insulin
Standard: 2.6 – 24.9 μIU/mL
Optimal: < 5 μIU/mL
Insulin resistance is an independent cardiovascular risk factor that drives hypertension, dyslipidemia (high triglycerides, low HDL, small dense LDL), endothelial dysfunction, and chronic inflammation. Rises years before blood sugar abnormalities appear — an early warning signal most doctors miss.
Tier 1 (Essential)
Tier 2 (Advanced)
Lipid Optimization
Standard reference ranges tell you when disease is present. Optimal ranges tell you how to prevent disease from ever starting.
Conventional Target
< 200 mg/dL
Functional Optimal
Context-dependent (TC alone is a poor predictor)
Total cholesterol is a crude metric. Many heart attacks occur in people with 'normal' TC. Focus on apoB, particle number, and inflammation instead.
Conventional Target
< 100 mg/dL (high risk: < 70)
Functional Optimal
< 100 mg/dL, but apoB is more informative
LDL-C can be discordant with LDL particle number. If LDL-C and apoB disagree, apoB wins as the better risk predictor.
Conventional Target
> 40 mg/dL (men), > 50 mg/dL (women)
Functional Optimal
> 60 mg/dL
HDL-C above 60 is cardioprotective. Raising HDL through exercise, omega-3s, and moderate alcohol is beneficial. Pharmaceutical HDL-raising has failed in trials — function matters more than concentration.
Conventional Target
< 150 mg/dL
Functional Optimal
< 80 mg/dL
Fasting TG above 150 indicates insulin resistance and atherogenic dyslipidemia. TG/HDL ratio below 2.0 is an excellent insulin sensitivity surrogate. Omega-3s, carb restriction, and exercise are the most effective non-pharmacological interventions.
Conventional Target
Not routinely calculated
Functional Optimal
< 1.5 (ideal < 1.0)
The strongest lipid-based predictor of insulin resistance and small, dense LDL particles. A ratio above 3.5 strongly suggests metabolic syndrome regardless of LDL-C. Easy to calculate from any standard lipid panel.
Conventional Target
< 130 mg/dL
Functional Optimal
< 80 mg/dL
The single best lipoprotein metric. If you can only test one thing beyond standard lipids, make it apoB. Directly counts atherogenic particles.
You can calculate this yourself from any standard lipid panel: simply divide your triglycerides by your HDL-C. This ratio is the single best lipid-based predictor of insulin resistance, small dense LDL particles, and metabolic syndrome. It is more predictive than LDL-C alone.
< 1.0
Excellent
1.0 - 2.0
Acceptable
> 3.5
High Risk
Blood Pressure Optimization
Hypertension is the leading modifiable risk factor for cardiovascular disease. These interventions can be stacked for cumulative effect.
The 2017 ACC/AHA guidelines redefined hypertension as blood pressure above 130/80 mmHg. By this standard, nearly half of U.S. adults have hypertension. The good news: many natural interventions have blood pressure effects comparable to first-line medications, and they can be stacked. Combining beetroot + magnesium + potassium + garlic + taurine can produce a cumulative reduction of 15-30+ mmHg systolic — equivalent to 1-2 pharmaceutical agents.
Nitrate → nitrite → nitric oxide pathway. Direct vasodilation via arterial smooth muscle relaxation.
6-8 mmol nitrate (400-500 mL beetroot juice or concentrated shot)
Potassium promotes renal sodium excretion (natriuresis), reduces vascular tone, and counteracts the hypertensive effects of sodium. The Na:K ratio matters more than sodium intake alone.
3,500-4,700 mg/day total (food + supplement). Potassium citrate or gluconate if supplementing.
Calcium channel blockade in vascular smooth muscle, inhibition of aldosterone, improved insulin sensitivity, and direct vasodilation. Over 50% of adults are deficient.
300-400 mg elemental magnesium daily (taurate or glycinate form)
Stimulates endothelial nitric oxide synthase (eNOS), increases hydrogen sulfide (vasodilator), inhibits ACE activity, and reduces arterial stiffness.
600-1,200 mg aged garlic extract daily (Kyolic)
Improves endothelial function, reduces oxidative stress in vascular walls, and may preserve nitric oxide bioavailability by scavenging superoxide.
100-300 mg ubiquinol daily
Improves arterial compliance, reduces arterial stiffness, and decreases peripheral vascular resistance through anti-inflammatory and vasodilatory eicosanoid production.
2-4 g combined EPA+DHA daily
Anthocyanins act as natural ACE inhibitors. Multiple RCTs confirm blood pressure reduction comparable to some first-line antihypertensives.
3 cups hibiscus tea daily (steep 5-10 minutes)
Modulates vascular smooth muscle calcium signaling, enhances NO production, and reduces sympathetic nervous system overactivity.
1-3 g taurine daily
Important: If you are on antihypertensive medication, do NOT stop or reduce your medication without your doctor's guidance. Add these interventions alongside medication and work with your physician to potentially titrate down as your blood pressure improves naturally. Always monitor blood pressure at home when making changes.
Vascular Health
The endothelium is a single-cell-thick lining of every blood vessel. When it's healthy, it produces nitric oxide, prevents clotting, and keeps arteries flexible. When it's damaged, atherosclerosis begins.
Nitric oxide (NO) is arguably the most important molecule in cardiovascular health. It was named “Molecule of the Year” by Science magazine in 1992, and the researchers who discovered its cardiovascular role won the Nobel Prize in 1998. NO is produced through two pathways:
Pathway 1: eNOS (enzymatic)
L-arginine is converted to NO by endothelial nitric oxide synthase (eNOS). Requires cofactors: BH4, NADPH, and calcium. This pathway declines with age, inflammation, and insulin resistance. Support with L-citrulline (converts to L-arginine in the kidneys) and vitamin C (regenerates BH4).
Pathway 2: Nitrate-Nitrite-NO
Dietary nitrate (from beetroot, leafy greens) is reduced to nitrite by oral bacteria, then to NO in acidic environments (stomach, ischemic tissue). This pathway becomes MORE important with aging as eNOS function declines. Antibacterial mouthwash destroys this pathway entirely.
The Evidence
These are not observational correlations. These are large, randomized controlled trials and prospective cohort studies that have shaped cardiovascular medicine.
4 g/day pure EPA reduced major cardiovascular events by 25% and cardiovascular death by 20%
Subjects: 8,179 statin-treated patients with elevated triglycerides
Proved that high-dose omega-3 (EPA specifically) provides cardiovascular benefit beyond statins. Led to FDA approval of icosapent ethyl (Vascepa).
CoQ10 (300 mg/day) reduced cardiovascular mortality by 43% in heart failure patients over 2 years
Subjects: 420 patients with moderate-to-severe heart failure across 17 countries
First large, randomized trial to show CoQ10 reduces hard cardiovascular endpoints (death and hospitalization). Landmark for mitochondrial medicine.
Red yeast rice reduced heart attacks by 45%, coronary death by 33%, and total mortality by 33%
Subjects: 4,870 Chinese patients with previous heart attack, followed 4.5 years
Demonstrated that a natural statin (monacolin K from red yeast rice) produces cardiovascular outcomes comparable to pharmaceutical statins.
Aged garlic extract slowed coronary artery calcium progression by 80% vs placebo over 12 months
Subjects: Subjects with measurable coronary artery calcium on CT scan
One of the first supplements to demonstrate objective slowing of atherosclerotic plaque progression using imaging endpoints.
Highest vitamin K2 intake reduced cardiovascular mortality by 57% and aortic calcification by 52%
Subjects: 4,807 healthy subjects followed 7-10 years in the Netherlands
Established vitamin K2 as a critical nutrient for cardiovascular health, distinct from K1 (which showed no benefit).
4-7 sauna sessions per week reduced cardiovascular mortality by 50% and sudden cardiac death by 63%
Subjects: 2,315 Finnish men followed for 20+ years
The strongest epidemiological evidence for heat therapy and cardiovascular health. Dose-response relationship: more frequent sauna = lower risk.
Treating elevated hs-CRP (even with normal LDL-C) reduced cardiovascular events by 44%
Subjects: 17,802 apparently healthy people with LDL-C < 130 but hs-CRP above 2.0 mg/L
Proved that inflammation is an independent cardiovascular risk factor and that hs-CRP is a clinically actionable biomarker.
Your Action Plan
Don't try to do everything at once. This 3-level protocol builds systematically — each level compounds the benefits of the one before it.
Weeks 1-4 — Assess and clean up the basics
The goal is to establish baselines, remove inflammatory dietary triggers, and build foundational habits. Most people see improvements in triglycerides, blood pressure, and energy within 2-3 weeks of eliminating seed oils and adding magnesium and potassium-rich foods.
Weeks 5-12 — Stack supplements and build fitness
This is where targeted supplementation and structured exercise start moving biomarkers. Zone 2 cardio is the single most important exercise modality for cardiovascular health — it improves mitochondrial density, capillary density, and aerobic capacity without excessive stress on the heart.
Month 4+ — Full cardiovascular optimization
At this level, you are deploying every evidence-based tool available: optimized supplementation, advanced biomarker tracking, nitric oxide optimization, vascular training through thermal therapy, and metabolic health. Track quarterly to confirm your biomarkers are moving in the right direction. The goal: apoB below 80, hs-CRP below 0.5, omega-3 index above 8%, TG/HDL below 1.5, blood pressure below 120/80, fasting insulin below 5.
FAQ
Inflammation
Chronic inflammation drives atherosclerosis. Learn the biomarkers, nutrition, and protocols to resolve it.
Biomarkers
The 20 key metrics for healthspan, including cardiovascular markers with optimal ranges and testing protocols.
Electrolytes
Potassium, magnesium, and sodium balance are critical for blood pressure and cardiac rhythm.
This guide gives you the science. A CryoCove coach gives you the personalization — which biomarkers to prioritize, how to sequence your supplements, which lifestyle pillars will move the needle fastest for your unique risk profile, and ongoing accountability as your numbers improve.